Life Science Buffers

Balanced salt solutions and powders used for molecular, protein, nucleic acid, and cell biology applications including cell culture, electrophoresis, ELISA, and chromatography processes; available in a variety of formulations and grades.

Buffer solutions serve to keep pH (acidity or alkalinity) nearly constant in a variety of chemical and biological applications. For example, a bicarbonate buffer helps maintain the pH of blood, a buffered saline maintains cellular contents at a consistent pH level, and buffers help maintain a narrow pH range for enzymes to function correctly.

Most biological samples used in research are kept at a pH of about 7.4. Common biological buffers used for tissue culture include Dulbeccos phosphate buffered saline (PBS), Tris base, HEPES, MOPS, PIPES, and other formulations developed for specific cell lines or applications. Most buffers used in cell culture are also DNase-, RNase-, and protease-free.

The choice of buffer for a particular biological reaction or site depends on several factors:

Temperature
Desired or target pH
Buffer toxicity (to the system)
Buffer interactions with other system components

331 – 345 of 3,304 results

331

Thermo Scientific Chemicals TRIS, 1.0M buffer soln., pH 6.5

CAS: 77-86-1 Molecular Formula: C4H11NO3 Molecular Weight (g/mol): 121.136 MDL Number: MFCD00004679 InChI Key: LENZDBCJOHFCAS-UHFFFAOYSA-N PubChem CID: 6503 ChEBI: CHEBI:9754 IUPAC Name: 2-amino-2-(hydroxymethyl)propane-1,3-diol SMILES: C(C(CO)(CO)N)O

Pricing & Availability
Specifications

PubChem CID	6503
CAS	77-86-1
Molecular Weight (g/mol)	121.136
ChEBI	CHEBI:9754
MDL Number	MFCD00004679
SMILES	C(C(CO)(CO)N)O
IUPAC Name	2-amino-2-(hydroxymethyl)propane-1,3-diol
InChI Key	LENZDBCJOHFCAS-UHFFFAOYSA-N
Molecular Formula	C4H11NO3

332

MP Biomedicals™ MOPS SDS Running Buffer for Bis-Tris Gels, Powder

Powder MOPS buffer salts to make PAGE buffer.

Pricing & Availability

333

MP Biomedicals™ Phosphate Buffered Saline (PBS), Dulbecco's formula, without Magnesium and Calcium

DPBS Powder

Pricing & Availability

334

Thermo Scientific Chemicals PIPES, 98.5+%, for biochemistry

CAS: 5625-37-6 Molecular Formula: C8H18N2O6S2 Molecular Weight (g/mol): 302.36 InChI Key: IHPYMWDTONKSCO-UHFFFAOYSA-N Synonym: 1, 4-Piperazinebis(ethanesulfonic acid) PubChem CID: 79723 ChEBI: CHEBI:44933 IUPAC Name: 2-[4-(2-sulfoethyl)piperazin-1-yl]ethanesulfonic acid SMILES: C1CN(CCN1CCS(=O)(=O)O)CCS(=O)(=O)O

Pricing & Availability
Specifications

PubChem CID	79723
CAS	5625-37-6
Molecular Weight (g/mol)	302.36
ChEBI	CHEBI:44933
SMILES	C1CN(CCN1CCS(=O)(=O)O)CCS(=O)(=O)O
Synonym	1, 4-Piperazinebis(ethanesulfonic acid)
IUPAC Name	2-[4-(2-sulfoethyl)piperazin-1-yl]ethanesulfonic acid
InChI Key	IHPYMWDTONKSCO-UHFFFAOYSA-N
Molecular Formula	C8H18N2O6S2

335

MilliporeSigma™ Calbiochem™ OmniPur™ TBE Buffer, 10X

Suitable for a wide range of molecular biology applications. Each liter of 10X TBE buffer yields 10 liters of 1X TBE buffer.

Pricing & Availability
Specifications

Physical Form	Liquid

336

MOPS Hemisodium Salt, Biological Buffer, Spectrum™ Chemical

CAS: 117961-20-3 Molecular Formula: C14H29N2NaO8S2 Molecular Weight (g/mol): 440.50 InChI Key: OVCWZKQPQOVIDT-UHFFFAOYSA-M IUPAC Name: sodium 3-(morpholin-4-yl)propane-1-sulfonic acid 3-(morpholin-4-yl)propane-1-sulfonate SMILES: [Na+].OS(=O)(=O)CCCN1CCOCC1.[O-]S(=O)(=O)CCCN1CCOCC1

Pricing & Availability
Specifications

CAS	117961-20-3
Molecular Weight (g/mol)	440.50
SMILES	[Na+].OS(=O)(=O)CCCN1CCOCC1.[O-]S(=O)(=O)CCCN1CCOCC1
IUPAC Name	sodium 3-(morpholin-4-yl)propane-1-sulfonic acid 3-(morpholin-4-yl)propane-1-sulfonate
InChI Key	OVCWZKQPQOVIDT-UHFFFAOYSA-M
Molecular Formula	C14H29N2NaO8S2

337

HEPPSO, 99%, MP Biomedicals

CAS: 68399-78-0 Molecular Formula: C9H20N2O5S Molecular Weight (g/mol): 268.328 InChI Key: GIZQLVPDAOBAFN-UHFFFAOYSA-N Synonym: heppso,2-hydroxy-3-4-2-hydroxyethyl piperazin-1-yl propane-1-sulfonic acid,n-hydroxyethyl piperazine-n'-2-hydroxypropanesulfonic acid,beta-hydroxy-4-2-hydroxyethyl piperazine-1-propanesulphonic acid,beta-hydroxy-4-2-hydroxyethyl-1-piperazinepropanesulfonic acid,3-4-2-hydroxyethyl-1-piperazinyl-2-hydroxypropanesulfonic acid,4-2-hydroxyethyl piperazine-1-2-hydroxypropane-3-sulfonic acid,4-2-hydroxyethyl piperazine-1-2-hydroxypropane sulfonic acid free acid,2-hydroxy-3-4-2-hydroxyethyl piperazinyl propanesulfonic acid PubChem CID: 100205 ChEBI: CHEBI:32951 IUPAC Name: 2-hydroxy-3-[4-(2-hydroxyethyl)piperazin-1-yl]propane-1-sulfonic acid SMILES: C1CN(CCN1CCO)CC(CS(=O)(=O)O)O

Pricing & Availability
Specifications

PubChem CID	100205
CAS	68399-78-0
Molecular Weight (g/mol)	268.328
ChEBI	CHEBI:32951
SMILES	C1CN(CCN1CCO)CC(CS(=O)(=O)O)O
Synonym	heppso,2-hydroxy-3-4-2-hydroxyethyl piperazin-1-yl propane-1-sulfonic acid,n-hydroxyethyl piperazine-n'-2-hydroxypropanesulfonic acid,beta-hydroxy-4-2-hydroxyethyl piperazine-1-propanesulphonic acid,beta-hydroxy-4-2-hydroxyethyl-1-piperazinepropanesulfonic acid,3-4-2-hydroxyethyl-1-piperazinyl-2-hydroxypropanesulfonic acid,4-2-hydroxyethyl piperazine-1-2-hydroxypropane-3-sulfonic acid,4-2-hydroxyethyl piperazine-1-2-hydroxypropane sulfonic acid free acid,2-hydroxy-3-4-2-hydroxyethyl piperazinyl propanesulfonic acid
IUPAC Name	2-hydroxy-3-[4-(2-hydroxyethyl)piperazin-1-yl]propane-1-sulfonic acid
InChI Key	GIZQLVPDAOBAFN-UHFFFAOYSA-N
Molecular Formula	C9H20N2O5S

338

MP Biomedicals™ Dulbecco's Phosphate Buffered Saline (10X) without Calcium and Magnesium

Stock solution used to prepare 1X D-PBS in cell culture grade water.

Pricing & Availability

339

PIPES, ≥99%, Molecular Biology Reagent Grade, MP Biomedicals™

CAS: 5625-37-6 Molecular Formula: C8H18N2O6S2 Molecular Weight (g/mol): 302.36 MDL Number: MFCD00006159 InChI Key: IHPYMWDTONKSCO-UHFFFAOYSA-N Synonym: Piperazine-N, N'-bis[2-ethanesulfonic acid] PubChem CID: 79723 ChEBI: CHEBI:44933 IUPAC Name: 2-[4-(2-sulfoethyl)piperazin-1-yl]ethanesulfonic acid SMILES: C1CN(CCN1CCS(=O)(=O)O)CCS(=O)(=O)O

Pricing & Availability
Specifications

PubChem CID	79723
CAS	5625-37-6
Molecular Weight (g/mol)	302.36
ChEBI	CHEBI:44933
MDL Number	MFCD00006159
SMILES	C1CN(CCN1CCS(=O)(=O)O)CCS(=O)(=O)O
Synonym	Piperazine-N, N'-bis[2-ethanesulfonic acid]
IUPAC Name	2-[4-(2-sulfoethyl)piperazin-1-yl]ethanesulfonic acid
InChI Key	IHPYMWDTONKSCO-UHFFFAOYSA-N
Molecular Formula	C8H18N2O6S2

340

Thermo Scientific Chemicals PIPES, 0.5M buffer soln., pH 6.8

CAS: 5625-37-6 Molecular Formula: C8H18N2O6S2 Molecular Weight (g/mol): 302.36 MDL Number: MFCD00006159 InChI Key: IHPYMWDTONKSCO-UHFFFAOYSA-N PubChem CID: 79723 ChEBI: CHEBI:44933 IUPAC Name: 2-[4-(2-sulfoethyl)piperazin-1-yl]ethanesulfonic acid SMILES: C1CN(CCN1CCS(=O)(=O)O)CCS(=O)(=O)O

Pricing & Availability
Specifications

PubChem CID	79723
CAS	5625-37-6
Molecular Weight (g/mol)	302.36
ChEBI	CHEBI:44933
MDL Number	MFCD00006159
SMILES	C1CN(CCN1CCS(=O)(=O)O)CCS(=O)(=O)O
IUPAC Name	2-[4-(2-sulfoethyl)piperazin-1-yl]ethanesulfonic acid
InChI Key	IHPYMWDTONKSCO-UHFFFAOYSA-N
Molecular Formula	C8H18N2O6S2

341

MilliporeSigma™ HEPES, Free Acid, OmniPur™, Calbiochem™,

CAS: 7365-45-9 Molecular Formula: C8H18N2O4S Molecular Weight (g/mol): 238.30 MDL Number: MFCD00006158 InChI Key: JKMHFZQWWAIEOD-UHFFFAOYSA-N Synonym: N-2-Hydroxyethylpiperazine-N'-2-ethanesulfonic acid PubChem CID: 23831 ChEBI: CHEBI:42334 IUPAC Name: 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethane-1-sulfonic acid SMILES: OCCN1CCN(CCS(O)(=O)=O)CC1

Pricing & Availability
Specifications

PubChem CID	23831
CAS	7365-45-9
Molecular Weight (g/mol)	238.30
ChEBI	CHEBI:42334
MDL Number	MFCD00006158
SMILES	OCCN1CCN(CCS(O)(=O)=O)CC1
Synonym	N-2-Hydroxyethylpiperazine-N'-2-ethanesulfonic acid
IUPAC Name	2-[4-(2-hydroxyethyl)piperazin-1-yl]ethane-1-sulfonic acid
InChI Key	JKMHFZQWWAIEOD-UHFFFAOYSA-N
Molecular Formula	C8H18N2O4S

342

bis-Tris, ≥99%, MP Biomedicals™

CAS: 6976-37-0 Molecular Formula: C8H19NO5 Molecular Weight (g/mol): 209.242 InChI Key: OWMVSZAMULFTJU-UHFFFAOYSA-N PubChem CID: 81462 ChEBI: CHEBI:41250 IUPAC Name: 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol SMILES: C(CO)N(CCO)C(CO)(CO)CO

Pricing & Availability
Specifications

PubChem CID	81462
CAS	6976-37-0
Molecular Weight (g/mol)	209.242
ChEBI	CHEBI:41250
SMILES	C(CO)N(CCO)C(CO)(CO)CO
IUPAC Name	2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol
InChI Key	OWMVSZAMULFTJU-UHFFFAOYSA-N
Molecular Formula	C8H19NO5

343

TAE 50X BUFFER, MP Biomedicals™

MDL Number: MFCD00236357 Synonym: Tris-Borate-EDTA Buffer

Pricing & Availability
Specifications

MDL Number	MFCD00236357
Synonym	Tris-Borate-EDTA Buffer

344

MilliporeSigma™ Tricine, ULTROL™ Grade, Calbiochem™,

CAS: 4-1-5704 Molecular Formula: C6H13NO5 Molecular Weight (g/mol): 179.17 InChI Key: SEQKRHFRPICQDD-UHFFFAOYSA-N Synonym: N-[tris(Hydroxymethyl)methyl]glycine PubChem CID: 79784 ChEBI: CHEBI:39063 IUPAC Name: 2-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]acetic acid SMILES: C(C(=O)O)NC(CO)(CO)CO

Pricing & Availability
Specifications

PubChem CID	79784
CAS	4-1-5704
Molecular Weight (g/mol)	179.17
ChEBI	CHEBI:39063
SMILES	C(C(=O)O)NC(CO)(CO)CO
Synonym	N-[tris(Hydroxymethyl)methyl]glycine
IUPAC Name	2-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]acetic acid
InChI Key	SEQKRHFRPICQDD-UHFFFAOYSA-N
Molecular Formula	C6H13NO5

345

HEPES Sodium Salt, Cell Culture Reagent Grade, ≥98.0%, MP Biomedicals™

CAS: 75277-39-3 Molecular Formula: C8H17N2NaO4S Molecular Weight (g/mol): 260.28 MDL Number: MFCD00036463 InChI Key: RDZTWEVXRGYCFV-UHFFFAOYSA-M Synonym: 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid sodium salt,N-(2-Hydroxyethyl)piperazine-N-(2-ethanesulfonic acid) sodium salt PubChem CID: 2724248 ChEBI: CHEBI:46758 IUPAC Name: sodium 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethane-1-sulfonate SMILES: [Na+].OCCN1CCN(CCS([O-])(=O)=O)CC1

Pricing & Availability
Specifications

PubChem CID	2724248
CAS	75277-39-3
Molecular Weight (g/mol)	260.28
ChEBI	CHEBI:46758
MDL Number	MFCD00036463
SMILES	[Na+].OCCN1CCN(CCS([O-])(=O)=O)CC1
Synonym	4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid sodium salt,N-(2-Hydroxyethyl)piperazine-N-(2-ethanesulfonic acid) sodium salt
IUPAC Name	sodium 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethane-1-sulfonate
InChI Key	RDZTWEVXRGYCFV-UHFFFAOYSA-M
Molecular Formula	C8H17N2NaO4S

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MOPS Hemisodium Salt, Biological Buffer, Spectrum™ Chemical Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

MOPS Hemisodium Salt, Biological Buffer, Spectrum™ Chemical